The role of selected mechanisms of innate immunity in the pathogenesis of diabetes

Understanding the important role of non-specific immune response in protecting body against development numerous diseases has become partially possible after discovery several classes pattern recognition receptors (PRR), such as Toll-like or NOD-like receptors. A group cytoplasmic proteins called inflammasome, which detect PAMP and DAMP through PRR receptors, is able to activate pro-inflammatory cytokines trigger an acute inflammatory reaction both extracellular intracellular space. Low-grade systemic local inflammation contributes progression various conditions, including autoimmune metabolic diseases, diabetes, syndrome atherosclerosis, until recently were not even considered diseases. This review will discuss innate immunity type 1 2 focusing on specific insulin resistance involved these pathogenesis.